Evidence map›Paper›PMID 41289021›Full record

ArticleThe Journal of clinical investigation2026

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

Antonio Carlos Tallon-Cobos, Konstantinos Vazaios, Piotr Waranecki, Marliek van Hoesel, Annelisa Cornel, Benjamin Schwalm, Norman Mack, Ella de Boed, Jasper van der Lugt, Stefan Nierkens and 4 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A brief history of ependymoma.Neuro-oncology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antonio Carlos Tallon-CobosPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Konstantinos VazaiosPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Piotr WaraneckiPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Marliek van HoeselPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Annelisa CornelPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Benjamin SchwalmHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Norman MackHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Ella de BoedPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Jasper van der LugtPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Stefan NierkensPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Marcel KoolPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Eelco W HovingPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Dennis S MetselaarPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.
Esther HullemanPrincess Máxima Center for pediatric oncology, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.

Indexed as

Brain NeoplasmsEpendymomaGangliosidesImmunotherapy, AdoptiveReceptors, Chimeric AntigenAnimalsCell Line, TumorDisease Models, AnimalHumansMiceXenograft Model Antitumor Assaysganglioside, GD2GangliosidesReceptors, Chimeric AntigenBrain cancerCancer immunotherapyImmunologyNeuroscienceOncology

Identifiers

PMID41289021
PMCPMC12807483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.