Evidence map›Paper›PMID 41289000›Full record

ArticleNanoscale2025

Near-infrared imaging of intraperitoneal ovarian cancer enhanced by BrCy112 in a dual mode (MR and NIR), dual-Gd nanoparticle.

Bonghwan Chon, Mukesh P Yadav, William Ghann, Jamal Uddin, Bahman Anvari, Vikas Kundra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bonghwan ChonDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA. vkundra@som.umaryland.edu.ORCID http://orcid.org/0000-0002-3882-1045
Mukesh P YadavDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA. vkundra@som.umaryland.edu.
William GhannCenter for Nanotechnology, Department of Natural Sciences, Coppin State University, 2500 W North Ave, Baltimore, MD 21216, USA.ORCID http://orcid.org/0000-0001-5698-8810
Jamal UddinCenter for Nanotechnology, Department of Natural Sciences, Coppin State University, 2500 W North Ave, Baltimore, MD 21216, USA.ORCID http://orcid.org/0000-0002-6714-9286
Bahman AnvariDepartment of Bioengineering, University of California, Riverside, 900 University Ave, Riverside, CA 92521, USA.ORCID http://orcid.org/0000-0002-2511-5854
Vikas KundraDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA. vkundra@som.umaryland.edu.ORCID http://orcid.org/0000-0002-3262-4059

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Multimodal Imaging and Therapy of Ovarian CancerR01CA255753 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VIKAS KUNDRA · 2021 to 2026
$2.7M
NCI NIH HHS P30 CA134274NCI NIH HHS R01 CA255753
6 · The paper itself

Abstract

Dual-Mode-Dual-Gd (DMDG) nanoparticles incorporating BrCy112, a brominated carbocyanine dye, were investigated for their potential in magnetic resonance (MR) and optical imaging of intraperitoneal ovarian tumors in an animal model two days post-intravenous injection. DMDG nanoparticles were synthesized using either BrCy112 or indocyanine green (ICG) as the near-infrared (NIR) fluorophore, combined with positive contrast MR imaging agents. The optical properties of these fluorophores were characterized through absorption and fluorescence (FL) spectroscopy, with their loading concentrations optimized in liposomal formulations. MR relaxivity and FL intensity were assessed

Indexed as

CarbocyaninesContrast MediaGadoliniumMagnetic Resonance ImagingMetal NanoparticlesNanoparticlesOvarian NeoplasmsAnimalsCell Line, TumorFemaleFluorescent DyesHumansIndocyanine GreenLiposomesMiceMice, NudeCarbocyaninesContrast MediaFluorescent DyesGadoliniumIndocyanine GreenLiposomes

Identifiers

PMID41289000
PMCPMC13335723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.