Extreme Heat, Social Factors, and Mortality Among California Veterans With Cardiometabolic Disease.

Importance: There is limited research investigating associations between extreme heat events (EHEs) and adverse outcomes for veterans and high-risk veteran subpopulations. Objectives: To investigate the association between EHEs and mortality among California veterans with common cardiometabolic diseases and to examine how this risk differs by race and ethnicity, neighborhood health-related social risk factors, and history of homelessness. Design, Setting, and Participants: This case-crossover study used administrative data from the Veterans Health Administration (VA) Corporate Data Warehouse to identify veterans with a California address from October 1, 2015, to September 30, 2021, and a diagnosis of a cardiometabolic condition of hypertension, diabetes, ischemic heart disease, congestive heart failure, chronic kidney disease, stroke, or peripheral arterial disease. Data were analyzed from October 2023 to December 2024. Exposure: Date- and address-specific EHEs as defined by daily maximum temperatures greater than the 90th, 95th, and 97.5th percentiles of 2006 to 2020 historical normal temperatures derived from National Center for Environmental Information meteorological data. Patient residential addresses were linked with the nearest weather station. The associations of same-day to 4-day EHEs with mortality were assessed. Main Outcomes and Measures: The main outcome was individual all-cause mortality during warm months (April-October). A time-stratified case-crossover design with conditional logistic regression was used to investigate associations between EHEs and mortality. Planned exploratory subgroup analyses were performed by race and ethnicity, Area Deprivation Index (ADI) for patient address, and homeless status. Results: A total of 13 556 veterans (median age, 78 years [IQR, 71-87 years]; 13 265 men [97.9%]) experienced mortality during the study period. Extreme heat events were significantly associated with mortality at all percentile thresholds (eg, at 95th percentile odds ratio [OR] range, 1.10 [95% CI, 1.04-1.17] to 1.14 [95% CI, 1.08-1.20]; P = .005). Effect estimates were greater for veterans in high vs lower ADI neighborhoods (eg, 3-day EHEs at 95th percentile: OR, 1.44 [95% CI, 1.15-1.80] vs OR, 1.12 [95% CI, 1.06-1.19]), and veterans who experienced homelessness compared with those who did not (eg, 3-day EHEs at 95th percentile: OR, 1.25 [95% CI, 1.09-1.45] vs OR, 1.12 [95% CI, 1.05-1.19]) across EHE definitions, although there was no statistically significant effect modification. Conclusions and Relevance: In this study of California veterans with common cardiometabolic diseases, EHEs were significantly associated with mortality. These results suggest that the VA should develop EHE risk-mitigating interventions to protect veterans, particularly those at greatest risk, from heat-related mortality.