ArticleMethods in molecular biology (Clifton, N.J.)2025
Transcription Factor Driven Generation of Vascular Organoids from Induced Pluripotent Stem Cells.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We present a streamlined method for generating vascularized organoids through transcription factor-mediated induction. Naïve (2iL) Mouse embryonic stem cells are lentivirally transduced with Etv2 and Nkx3.1, followed by clonal selection and conversion into epiblast-like cells (EpiLCs). This approach bypasses the need for exogenous growth factor supplementation and extracellular matrix embedding, resulting in the spontaneous formation of 3D vascular spheroids composed of integrated endothelial and mural cell networks. The resulting organoids exhibit functional vascular organization and provide a simple, reproducible platform for studying vascular development and tissue regeneration within a physiologically relevant 3D microenvironment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.