Evidence map›Paper›PMID 41288901›Full record

ArticleMolecular diversity2026

Novel oleanolic acid derivatives containing piperazine pyrimidine moieties: design, synthesis, and antimicrobial activity.

Fengwei Ma, Qingfang Deng, Yihao Lu, Zhenghong Jia, Su Xu, Qiang Fei, Haijiang Chen, Wenneng Wu

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fengwei Ma *School of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China.
Qingfang Deng *Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang, 550025, Guizhou, China.
Yihao Lu *School of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China.
Zhenghong JiaSchool of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China.
Su XuSchool of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China.
Qiang FeiSchool of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China.
Haijiang ChenSchool of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China. b05chenhj@126.com.
Wenneng WuSchool of Food Science and Engineering, Guiyang University, Guiyang, 550005, Guizhou, China. wuwenneng123@126.com.

Funding

Guizhou Provincial Education Department Qian Jiao Ji [2023]042Guizhou Provincial Science and Technology Projects Qian Ke He Cheng Guo-QKHCG [2023] YB090Guizhou Provincial Science and Technology Projects Qian Ke He Pingtai Rencai-CXTD [2022] 002The special funding of Guiyang science and technology bureau and Guiyang University GYU-KY [2021]
6 · The paper itself

Abstract

Natural products are main sources of new chemical entities for pesticide discovery and also important modification substrates for activity enhancement. In this study, a series of novel oleanolic acid derivatives containing piperazine pyrimidine structures were designed and synthesized. Multi NMR and high resolution-mass spectrometry technologies were utilized to characterize the synthesized compounds' structures. Antimicrobial potential of the title compounds was assessed against several phytopathogenic fungi and bacteria, namely Botryosphaeria dothidea, Fusarium sp. in morchella esculenta, Sclerotinia sclerotiorum, Fusarium graminearum, Rhizoctonia solani, Botrytis cinerea in strawberry, Botrytis cinerea in tobacco, Botrytis cinerea in blueberry, Alternaria solani, and Phomopsis sp., and Pseudomonas syringae pv. actinidiae, Xanthomonas oryzae pv. oryzicola, and Xanthomonas axonopodis pv. citri. The results showed that most of these compounds displayed good-to-moderate antimicrobial activities. Among them, compound 4e showed excellent efficacy against B. dothidea with EC

Indexed as

Anti-Infective AgentsDrug DesignOleanolic AcidPiperazinePiperazinesPyrimidinesAnti-Bacterial AgentsAntifungal AgentsBacteriaFungiMicrobial Sensitivity TestsMolecular Docking SimulationPlant DiseasesStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsOleanolic AcidPiperazinePiperazinespyrimidinePyrimidinesAntimicrobial activityBotryosphaeria dothideaKiwifruit soft rotOleanolic acidPiperazine pyrimidine

Identifiers

PMID41288901

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.