Evidence map›Paper›PMID 41288865›Full record

ArticleMolecular neurobiology2025

Potential Drug Targets for Migraine Identified Through Mendelian Randomization Analysis of the Human Plasma Proteome.

Longxin Guo, Jian Li, Zhe Chen, Xinyue Zhang, Chengxian Li

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Longxin GuoSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jian LiCollege of Pharmaceutical Science, Dali University, Dali, Yunnan, 671000, China.
Zhe ChenEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xinyue ZhangInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Chengxian LiEvidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. chengxianli2017tjutcm@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a common chronic condition with a clear need for innovative treatment approaches. Protein quantity trait loci (pQTLs), which specifically regulate protein expression levels, are the closest and most stable QTLs to the phenotypes under study. In this context, we employ plasma proteomes data to conduct Mendelian randomization and colocalization analysis to identify potential drug targets for migraine. Plasma proteome data were sourced from the Decode, UKB-PPP, and Interval databases. We selected cis-SNPs associated with plasma protein levels at a genome-wide significance level (p < 5 × 10

Indexed as

Blood ProteinsMendelian Randomization AnalysisMigraine DisordersMolecular Targeted TherapyProteomeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideBlood ProteinsProteomeDrug targetsMendelian randomizationMigrainePlasma protein

Identifiers

PMID41288865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.