Evidence map›Paper›PMID 41288775›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Dueling diagnosis of cancer and cognitive impairment: exploring the association of cognitive impairment with survival using the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study.

Erin Stevens, Eric M McLaughlin, Michael Pennell, Yesol Yang, Eric S Emerick, Sri Rajamouli, Electra D Paskett, Diane Von Ah, Ashley E Rosko

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Erin StevensDivision of Palliative Care, Department of Medicine, The Ohio State University, Columbus, USA. erin.stevens@osumc.edu.
Eric M McLaughlinCenter for Biostatistics, The Ohio State University, Columbus, USA.
Michael PennellDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, USA.
Yesol YangCollege of Nursing, The Ohio State University, Columbus, USA.
Eric S EmerickComprehensive Cancer Center, The Ohio State University, Columbus, USA.
Sri RajamouliDepartment of Hematology and Oncology, Loyola University Medical Center, Chicago, USA.
Electra D PaskettComprehensive Cancer Center, The Ohio State University, Columbus, USA.
Diane Von AhComprehensive Cancer Center, The Ohio State University, Columbus, USA.
Ashley E RoskoComprehensive Cancer Center, The Ohio State University, Columbus, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe incidence and prevalence of both cancer and dementia is rapidly increasing. Older adults with cognitive impairment (CI) may be more susceptible to adverse outcomes when diagnosed with cancer. The primary objective of this study was to examine the impact of CI on overall survival for post-menopausal women before and after a cancer diagnosis.

methodsData from the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study were used to examine overall survival of a unique cohort of LILAC participants screened for cognitive impairment. Cox proportional hazards regression was used for overall survival.

results592 participants were included in the analysis. Median age was 76 (range 73-79). 15.5% of participants had CI prior to their cancer diagnosis and 17.7% of patients had CI ever. All cancer types were included with the majority having breast (44%), lung (18%), and colorectal (18%). In a regression analysis, pre-existing CI (HR 1.48, 95%CI 1.11-1.97) and CI ever (pre- or post-diagnosis) (HR 1.66, 95%CI 1.20-2.29) were associated with worse overall survival. However, these associations were not significant following adjustments for prognostic factors of survival, CI pre (HR 1.23, 95%CI 0.91-1.67) and CI ever (HR 1.26, 95%CI 0.88-1.80).

conclusionThe association between CI and overall survival was not significant when adjusted for covariates. The sample size was small and included mostly white females with breast cancer. A larger sample with additional sub analysis will be important to examine overall survival in this population.

Indexed as

Cognitive DysfunctionNeoplasmsAgedCohort StudiesFemaleHumansLongevityPostmenopauseProportional Hazards ModelsWomen's HealthCancerCognitive impairmentWomen’s health

Identifiers

PMID41288775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.