Observational studyJournal of anesthesia2026
Comparison of preoperative neutrophil-percentage-to-albumin ratio, systemic immune-inflammatory index, and neutrophil-to-lymphocyte ratio for predicting postoperative delirium in patients undergoing head and neck free-flap reconstruction surgery: a retrospective observational study.
Observational study in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Reply to the letter by Eylem Yaşar et al.Journal of anesthesia · 2026Article
- Reply to the letter by Xiaonan Wang.Journal of anesthesia · 2026Article
- Reply to the letter by Xiaoli Zhao and Yi Deng.Journal of anesthesia · 2026Article
- Letter to the article by Saito et al.Journal of anesthesia · 2026Article
- Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
purposeReports on postoperative delirium (POD), neutrophil-percentage-to-albumin ratio (NPAR), and systemic immune-inflammatory index (SII) are limited. We aimed to compare the accuracy of preoperative NPAR, SII, and neutrophil-to-lymphocyte ratio (NLR) in predicting POD in patients undergoing head and neck free-flap reconstruction.
methodsThis single-center, observational, retrospective study in Japan included 184 patients who underwent head and neck free-flap reconstruction. POD was diagnosed using the Intensive Care Delirium Screening Checklist. Multivariable logistic regression analyses were conducted to evaluate the association of preoperative NPAR, SII, and NLR with POD. Receiver operating characteristic (ROC) curves were used to compare the accuracy of each inflammatory marker in predicting POD.
resultsSeven patients were excluded, leaving 177 patients (52 females, 125 males). Of these, 38 (21.5%) were diagnosed with POD. Multivariable logistic regression showed that preoperative NPAR, SII, and NLR were significantly associated with POD in patients undergoing head and neck free-flap reconstruction surgery. The areas under the ROC curve of NPAR, SII, and NLR were 0.78 (95% confidence interval: 0.69-0.86), 0.72 (0.62-0.82), and 0.75 (0.66-0.84), respectively.
conclusionThe Preoperative NPAR and SII were significantly correlated with POD in patients undergoing head and neck reconstruction, similar to NLR. Preoperative NPAR might serve as an established marker in predicting POD in patients undergoing head and neck free-flap reconstruction.
Indexed as
Identifiers
41288724What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.