ArticleMicrobial genomics2025
Global transcriptional reprogramming by cytomegalovirus infection suppresses MHC class II antigen presentation while enhancing migration machinery in murine dendritic cells.
Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- From genes to clinical application: a circulating four-gene signature for early diagnosis model of refractoryFrontiers in cellular and infection microbiology · 2026Article
- Global transcriptional reprogramming by cytomegalovirus infection suppresses MHC class II antigen presentation while enhancing migration machinery in murine dendritic cells.Microbial genomics · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) serve dual roles in cytomegalovirus infection: orchestrating antiviral immunity and acting as vehicles for viral dissemination. DC-dependent systemic spread of mouse cytomegalovirus (MCMV) is dependent on the expression of a viral G protein-coupled receptor homologue, encoded by M33. We performed global transcriptional profiling of murine DCs infected with either WT mouse MCMV or an M33 mutant harbouring a single point mutation (R131Q; denoted M33NQY), which ablates constitutive G protein-dependent signalling. RNA-seq analysis revealed that MCMV induces substantial transcriptional reprogramming, with over 2,400 significantly altered genes affecting key immune and migration pathways. WT MCMV infection resulted in 1,883 upregulated and 658 downregulated genes, while M33NQY infection showed comparable effects with 1,905 upregulated and 668 downregulated genes. Both viruses systematically downregulated the MHC class II antigen presentation machinery, with substantial suppression of H2 molecules, peptide-loading components (
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