Observational studyAnnals of African medicine2026
Vitamin D Status and Clinical Outcomes in Pediatric Idiopathic Nephrotic Syndrome: A Prospective Observational Study from North India.
Observational study in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundIdiopathic nephrotic syndrome frequently presents with Vitamin D deficiency due to urinary losses of Vitamin D-binding protein. The relationship between Vitamin D status and clinical outcomes remains incompletely understood.
objectiveTo evaluate Vitamin D status in children with idiopathic nephrotic syndrome and assess its association with remission time and relapse patterns. MATERIALS AND
methodsThis prospective observational study (October 2022-March 2024) included 60 children aged 1-14 years with idiopathic nephrotic syndrome at a tertiary care center in North India. The study involved 60 patients divided into supplemented (Group I, n = 30) and control (Group II, n = 30) groups. Vitamin D levels were measured at presentation, after 1 month, and at relapse events. Primary outcomes included baseline Vitamin D status, time to remission, and 6-month relapse rates.
resultsAll participants demonstrated Vitamin D deficiency (51.7%) or insufficiency (48.3%) at presentation. Children with relapses had significantly lower baseline Vitamin D levels compared to those with initial episodes (8.76 ± 2.75 vs. 15.78 ± 2.04 ng/mL, P < 0.001). Despite this association, time to remission was similar between groups with adequate versus inadequate Vitamin D status (11.60±3.2 vs 11.93 ± 3.4 days, p = 0.994). Six-month relapse rates showed no significant correlation with baseline Vitamin D levels ( r = -0.18, P = 0.17).
conclusionsVitamin D deficiency is universal in pediatric nephrotic syndrome, with lower levels observed in relapsing disease. However, Vitamin D status does not appear to significantly influence time to remission or short-term relapse patterns, suggesting its role may be primarily nutritional rather than therapeutic.
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