ArticleJournal of virology2025
Equine histones are mobilized within equid alphaherpesvirus 1 (EHV1) replication compartments.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Nucleolar proteins nucleolin and nucleophosmin 1 differentially relocalize during equid alphaherpesvirus 1 (EHV1) infection.Veterinary research communications · 2026Article
- Cross-Species Analysis of Transcriptomic Response to Alpha-Herpesvirus Infection in Human, Bovine and Equine Cells.International journal of molecular sciences · 2026Article
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1 author.
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Abstract
Equid alphaherpesvirus 1 (EHV1) is a DNA virus that causes severe disease in equids. Some strains are neurotropic and cause disease in the central nervous system, whereas others are non-neurotropic and can cause negative reproductive outcomes. Mechanisms governing EHV1 pathotype are not understood. However, EHV1 pathotypes have different infection efficiencies and replication kinetics in various cell types. They are also differentially susceptible to epigenetic inhibitors. Aside from this observation little is known about EHV1 chromatin or how its regulation influences infection. To build knowledge of EHV1 chromatin, we characterized equine histone mobility during EHV1 infection of equine cells using fluorescence recovery after photobleaching. We show that non-neurotropic or neurotropic EHV1 equally mobilized canonical (H2A, H2B, H3.1, and H4) and variant (H2A.B, H2A.Z, H2A.X, macroH2A, and H3.3) core and linker H1.2 histones. EHV1 mobilized dynamic histone populations by increasing their free pools and fast chromatin exchange. With the exception of H2A.B, all histones were most mobile within EHV1 replication compartments where EHV1 chromatin is enriched. Such mobility is consistent with highly dynamic viral chromatin. Distinct histone mobilities within EHV1- or infected-cell chromatin also indicate that different mechanisms regulate either chromatin. EHV1 mobilization of histones is similar to that reported for herpes simplex virus 1 (HSV1). This unique chromatin regulatory strategy is thus conserved among alphaherpesviruses in the
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