ArticleUnited European gastroenterology journal2026
Alcohol Use After TIPS Implantation Significantly Increases the Risk of ACLF and Liver-Related Death.
Article in United European gastroenterology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- UEG Journal-In Times of Turmoil, Science Matters.United European gastroenterology journal · 2026Article
- Alcohol Use After TIPS Implantation Significantly Increases the Risk of ACLF and Liver-Related Death.United European gastroenterology journal · 2026Article
- Should Elective TIPS be Placed in Non-Abstinent Patients With Alcohol-Related Cirrhosis?United European gastroenterology journal · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundComplications related to portal hypertension (PH) in patients with alcohol-related liver disease (ALD) can be controlled by transjugular intrahepatic portosystemic shunt (TIPS) placement; however, the impact of ongoing alcohol use (AU) after TIPS remains scarcely investigated.
methodsALD patients undergoing TIPS implantation between 2000 and 2022 were included. Laboratory/demographic parameters and clinical events/outcomes were compared per post-TIPS AU status and to a group of n = 55 decompensated ALD patients with ongoing AU who did not receive TIPS.
resultsOverall, 248 TIPS patients (78.2% male; median age: 55.5 years; ascites: 69.8%; median MELD: 12), including 90 (36.3%) with ongoing AU after TIPS were included. AU post-TIPS was independently associated with ACLF (asHR 2.27; 95% CI 1.40-3.66; p < 0.001) and liver-related death (asHR 1.68; 95% CI 1.05-2.67; p = 0.030) among patients undergoing TIPS in adjusted multivariable competing risks analysis. When comparing matched decompensated AU patients treated versus non-treated by TIPS, multivariable competing risks regression revealed MELD (asHR 1.07; 95% CI 1.01-1.13; p = 0.033) but not TIPS use (asHR 0.70; 95% CI 0.45-1.10; p = 0.120) as independent risk factors for ACLF, despite TIPS patients having higher levels of systemic inflammation (CRP).
conclusionPost-TIPS AU was frequent and an independent risk factor for ACLF and liver-related death, underlining the importance of interdisciplinary measures supporting alcohol abstinence. TIPS should still not be withheld from ALD patients developing PH complications, since it does not predispose them to ACLF and may prevent liver-related death.
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