Evidence map›Paper›PMID 41288339›Full record

ArticleApplied and environmental microbiology2025

A conserved C2H2 zinc finger protein, Rel1, links ribosome biogenesis to sexual development and antifungal susceptibility in a ubiquitous human fungal pathogen.

Lili Yan, Man Chen, Yuanli Liu, Pengjie Hu, Yan Wang, Yanli Cao, Ye Huang, Xiuyun Tian, Xinping Xu, Fanglin Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lili Yan *The Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Man Chen *The Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yuanli LiuDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical College, Ganzhou, Jiangxi, China.
Pengjie HuState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-0112-764X
Yan WangCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Yanli CaoSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ye HuangThe Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Xiuyun TianState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Xinping XuThe Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0002-9568-4171
Fanglin ZhengThe Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0009-0005-0329-0407

Funding

Ganpo Talent Support Program - Project for Cultivating Academic and Technical Leaders in Major Disciplines 20232BCJ23019National Natural Science Foundation of China 32160042National Natural Science Foundation of China 32200164National Natural Science Foundation of China 32360050National Natural Science Foundation of China 81772164National Natural Science Foundation of China 82360399Natural Science Foundation of Jiangxi Province 20212BAB216041Natural Science Foundation of Jiangxi Province 20224BAB216081
6 · The paper itself

Abstract

Sexual development is a fundamental process that promotes environmental adaptation and the emergence of highly virulent and drug-resistant isolates in the human fungal pathogen

Indexed as

Antifungal AgentsCryptococcus neoformansCYS2-HIS2 Zinc FingersFungal ProteinsRibosomesDrug Resistance, FungalGene Expression Regulation, FungalAntifungal AgentsFungal Proteinsantifungal susceptibilityCryptococcus neoformansRel1ribosome biogenesissexual reproduction

Identifiers

PMID41288339
PMCPMC12724378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.