Evidence map›Paper›PMID 41288197›Full record

ArticleJournal of the American Geriatrics Society2025

The Association of Frailty With Post-Hospital Discharge Location and Health Outcomes.

Charles T Semelka, Brian N White, Kathryn E Callahan, Nicholas M Pajewski

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charles T SemelkaDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-8137-1257
Brian N WhiteDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Kathryn E CallahanDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-6405-3062
Nicholas M PajewskiDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-4447-6196

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
Foundation of Post-Acute and Long-Term Care Medicine (2023 Pilot funding award)NCATS NIH HHS UM1 TR004929NIA NIH HHS P30 AG021332
6 · The paper itself

Abstract

backgroundPost-acute care (PAC) is designed to help older adults recover functional independence following hospitalization. Frailty is a predictor of adverse health outcomes in hospitalized older adults, but the impact on PAC remains unclear. The objective of this study was to investigate whether (1) frailty is associated with hospital discharge location and (2) the impact of frailty and discharge location on health outcomes.

methodsWe conducted a retrospective cohort study from a single US-based healthcare system from January 2021 to September 2023 of adults aged ≥ 65 years with an electronic frailty index (eFI) frailty score and hospital admission for at least 24 h. We evaluated the odds of hospital discharge location (home, home health services [HHS], and skilled nursing facility [SNF]) and health outcomes including hospital readmission and mortality, using logistic regression and Cox-regression models adjusted for demographics and healthcare system factors.

resultsA cohort of 23,407 older adult patients was included, with a mean age of 76.7 years (SD 7.7), 53% female sex, and 19% non-White race/ethnicity. Participant frailty was categorized as 22% non-frail, 46% pre-frail, 23% frail, and 8% severely frail. Patients with a higher degree of frailty were more likely to discharge with PAC (SNF or HHS) compared to home, adjusted odds ratio OR [95% CI], frail: OR 1.20 [1.09-1.33]. Frailty was a risk factor for 90-day hospital readmissions (OR 1.91 [1.67-2.20], p < 0.001) and mortality (HR 2.56 [2.10-3.13], p < 0.001) compared to non-frail individuals. In addition, patients discharged to SNF had higher mortality (HR 5.46 [4.43-6.73], p < 0.001), but did not have increased readmissions compared to individuals discharged home without HHS.

conclusionsFrailty in older adults was a risk factor for discharge to PAC, higher mortality, and readmissions. Automated frailty assessment can be used to identify high-risk patients, facilitating targeted interventions across the PAC continuum.

Indexed as

Frail ElderlyFrailtyPatient DischargePatient ReadmissionSubacute CareAgedAged, 80 and overFemaleGeriatric AssessmentHome Care ServicesHumansMaleRetrospective StudiesSkilled Nursing FacilitiesUnited Statescare transitionsfrailtyhospital readmissionspost‐acute care

Identifiers

PMID41288197
PMCPMC12645543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.