ArticleAnnals of African medicine2026
From Eye to Echo: Landolfi Sign as a Clue to Diagnosis of Severe Aortic Regurgitation.
Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractA 62-year-old male with a history of type II Diabetes Mellitus and recently diagnosed hypertension presented with progressive exertional dyspnea over 6 months, escalating from New York Heart Association Class II to Class IV within the past week. Clinical examination revealed a high-volume collapsing pulse and a wide pulse pressure. Notably, Landolfi's sign, alternating pupillary constriction and dilation synchronous with the cardiac cycle, was observed and documented via slit-lamp examination. Transthoracic echocardiography confirmed severe aortic regurgitation (AR) with an eccentric regurgitant jet, a regurgitant fraction of 71%, and a reduced left ventricular ejection fraction of 45%. The patient underwent successful aortic valve replacement with a bioprosthetic valve. This case underscores the significance of recognizing rare ocular signs in the clinical assessment of severe AR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.