ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Advancing Alzheimer's disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer's disease study (CPAS).Molecular psychiatry · 2026Review
- Sleep fragmentation correlates with amyloid beta deposition at brain autopsy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- FLOT1 and EEF1D: ac4C-related genes bridging Alzheimer's disease and sleep deprivation.Frontiers in aging neuroscience · 2026Article
- Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
introductionSleep problems are early features of Alzheimer's disease (AD). We examined domain-specific associations of subjective sleep with cognition, brain networks, and AD biomarkers in non-demented older adults.
methodsWe studied 849 non-demented participants from the Chinese Preclinical Alzheimer's Disease Study (CPAS) cohort. Subjective sleep dimensions were assessed, along with cognition, resting-state functional magnetic resonance imaging, [ DISCUSSION: Adequacy- and function-related sleep dimensions aligned with AD-related decline, whereas quantity- and fragmentation-related dimensions reflected network changes or subjective-objective discrepancies, suggesting distinct biological underpinnings of different sleep problems. HIGHLIGHTS: Different subjective sleep dimensions show distinct links with cognition and AD biomarkers. Sleep quality, efficiency, and daytime dysfunction relate to cognition, networks, and Aβ/tau. Shorter sleep and greater fragmentation show paradoxical associations with plasma biomarkers. Sleep alterations may involve heterogeneous biological pathways in the AD continuum. Multidimensional sleep assessment may improve early detection and risk stratification in AD.
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