SynthesisPeerJ2025
Effectiveness of multi-component exercise in individuals with type 2 diabetes: a systematic review and meta-analysis.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Effect of a Community Health Worker-Led Intervention on Physical Activity in Adults with Type 2 Diabetes in Primary Health Care in the Brazilian Amazon.International journal of environmental research and public health · 2026Trial
- Lifestyle intervention outcomes in T2DM and the added value of CGM: 6-month results from the Polish cohort of the C4D study.Scientific reports · 2026Article
- Article
- Metabolic Changes After the Implementation of a Recreational Physical Activity Program at Mexican Elderly Adults' Welfare Homes.Geriatrics (Basel, Switzerland) · 2026Article
- The effect of lifestyle interventions on cognitive function in patients with type 2 diabetes: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2026Review
- Type 2 Diabetes and Cognitive Dysfunction: Cardiorespiratory Fitness and Physical Activity Matters.Journal of diabetes research · 2026Article
- Latest advances and controversies of exercise therapy in the management of type 2 diabetes.Frontiers in endocrinology · 2026Review
- Targeting metabolic inflammation in type 2 diabetes mellitus through exercise: multi-level mechanisms of insulin resistance reversal and precision clinical translation - a review.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This meta-analysis aimed to explore the effects of multi-component exercise interventions on glycemic and lipid metabolism, physical fitness, and cognitive function in individuals with type 2 diabetes mellitus (T2DM). Methods: From inception to December 28, 2024, PubMed, Web of Science, Cochrane, and Elsevier databases were systematically searched for randomized controlled trials (RCTs) investigating multi-component exercise interventions for T2DM. A total of 37 articles, comprising 3,201 participants, were included. Primary and secondary outcome measures were categorized, summarized, and analyzed using RevMan 5.4 software. Results: Compared to control groups, multi-component exercise interventions produced statistically significant improvements across all measured outcomes in individuals with T2DM: (1) Glycemic control: HbA1c (standard mean difference (SMD) = -0.52, 95% confidence interval (CI) [-0.76 to -0.28]); fasting blood glucose (SMD = -0.53, 95% CI [-0.93 to -0.12]). (2) Lipid metabolism: high density lipoprotein (HDL) (SMD = 0.32, 95% CI [0.21-0.44]); low density lipoprotein (LDL) (SMD = -0.21, 95% CI [-0.33 to -0.09]); triglycerides (SMD = -0.18, 95% CI [-0.30 to -0.06]). (3) Physical fitness: upper limb strength (SMD = 0.67, 95% CI [0.51-0.83]); lower limb strength (SMD = 0.56, 95% CI [0.10-1.02]); peak oxygen consumption (SMD = 0.62, 95% CI [0.31-0.93]); body mass index (BMI) (SMD = -0.38, 95% CI [-0.67 to -0.09]). (4) Cognitive function: overall cognitive performance (SMD = 0.34, 95% CI [0.18-0.50]). (5) Quality of life: vitality (SMD = 0.37, 95% CI [0.09-0.64]); physical functioning (SMD = 0.48, 95% CI [0.20-0.75]); mental health (SMD = 0.35, 95% CI [0.07-0.63]); general health (SMD = 0.34, 95% CI [0.06-0.61]). Quality assessment indicated that the included studies were of high overall quality. Egger's regression analysis did not reveal significant publication bias. Conclusions: Multi-component exercise interventions significantly improved glycemic and lipid metabolism, physical fitness, and cognitive function in individuals with T2DM. These findings support the clinical value of incorporating multi-component exercise programs-particularly those performed at least three times per week and lasting 6 months or longer-into diabetes management strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.