Evidence map›Paper›PMID 41287848›Full record

ArticlePeerJ2025

DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer.

Chuan Zhou, Jia Wang, Han He, Chao Wang, YunFeng Zhang, Wenbo Zhang, Bin Wei, Mingxu Da, Minghui Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuan Zhou *Department of Geriatric General Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID 0009-0000-3693-265X
Jia Wang *The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Han HeThe First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Chao WangDepartment of Urology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
YunFeng ZhangThe First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Wenbo ZhangThe First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Bin WeiState Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Mingxu DaNHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou University, Lanzhou, Gansu, China.
Minghui PangDepartment of Geriatric General Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: 7-Dehydrocholesterol reductase (DHCR7) is an enzyme that plays a crucial regulatory role in sterol biosynthesis and has been implicated in tumorigenesis and progression. This study aims to elucidate the biological function of DHCR7 in the pathogenesis of colorectal cancer (CRC). Methods: By integrating multi-omics data (including public genomic databases and mass spectrometry data from clinical samples) and establishing Results: Elevated levels of sterols were observed in CRC tumor tissues, and high cholesterol levels were found to promote the malignant phenotype of tumor cells. Mass spectrometry revealed that DHCR7 was significantly upregulated in CRC tissues and correlated with poor clinical prognosis. DHCR7 could modulate the cholesterol levels in CRC cells; overexpression of this gene enhanced cell proliferation, inhibited apoptosis, and promoted invasion and migration. Conversely, inhibition of DHCR7 expression abrogated these pro-tumorigenic effects, which was consistent with the inactivation of the PI3K/AKT/mTOR signaling pathway and confirmed by pathway reactivation experiments. DHCR7 deficiency significantly reduced tumorigenicity Conclusion: DHCR7 regulates the progression of CRC both

Indexed as

CarcinogenesisColorectal NeoplasmsOxidoreductases Acting on CH-CH Group DonorsSterolsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationCholesterolFemaleGene Expression Regulation, NeoplasticHumansMaleMicePhosphatidylinositol 3-Kinases7-dehydrocholesterol reductaseCholesterolOxidoreductases Acting on CH-CH Group DonorsPhosphatidylinositol 3-KinasesSterolsTOR Serine-Threonine Kinases7-Dehydrocholesterol reductase (DHCR7)Colorectal cancerOncogenesisPI3K/AKT/mTOR signaling

Identifiers

PMID41287848
PMCPMC12640638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.