ArticleCureus2025
Association Between Postoperative Complications and Real-Time Oxidative Stress Measurements Using Electron Spin Resonance: An Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Surgical stress induces oxidative stress, which can affect postoperative recovery. Real-time monitoring of oxidative stress can provide valuable insights for perioperative management. This study aimed to investigate the relationship between perioperative oxidative stress and postoperative complications using real-time ascorbyl free radical (AFR) measurements via electron spin resonance (ESR). Methods Patients who underwent elective surgery were included in this study. Plasma samples were collected before and after surgery. Using the ESR spectrometer installed in the operating room, the intensity of the plasma AFR levels supplemented with dimethyl sulfoxide (AFR/DMSO) was measured. Clinical parameters, including the surgical Apgar score and National Surgical Quality Improvement Program-defined postoperative complications, were obtained from medical records. This study analyzed the relationship between the AFR/DMSO levels, surgical Apgar score, and postoperative complications. The perioperative factors influencing postoperative AFR/DMSO levels were also investigated. Results Postoperative AFR/DMSO levels were significantly lower than the preoperative values (0.26 vs. 0.32, P<0.001). Postoperative AFR/DMSO levels were positively correlated with the surgical Apgar score (r=0.25, P=0.002) and negatively correlated with the number of postoperative complications (r=-0.22, P=0.007). Multivariate analysis identified prolonged surgical duration and elevated postoperative inflammation markers as significant predictors of reduced postoperative AFR/DMSO. Conclusion ESR-based AFR/DMSO is a sensitive real-time indicator of oxidative stress and a valuable biomarker for predicting postoperative outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.