ArticleCureus2025
Connectome Analysis of the Nucleus Accumbens: Refining Radiosurgical Targeting for Addictive Disorders.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Radiomodulation-The Final Frontier of Radiosurgery?Brain sciences · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAddictions represent a major challenge not only for healthcare systems but also impose a significant socioeconomic burden affecting a large number of individuals worldwide. Various treatment modalities have been proposed, including pharmacological interventions, deep brain stimulation, and radiofrequency ablation, among others. Stereotactic radiosurgery has emerged as a non-invasive and precise alternative for addiction management. A thorough understanding of the nucleus accumbens (NAc) anatomy and its neural connections is essential to refine the radiosurgical target and optimize clinical outcomes. MATERIALS AND
methodsDiffusion tensor imaging was acquired from 3-Tesla and 1.5-Tesla Magnetic Resonance Imaging scanners on five healthy subjects, using T1 and T2 sequences. Images were fused, with autosegmentation of NAc, ventral tegmental area, amygdala, hippocampus, hypothalamus, and periventricular gray; insula, medial/lateral orbitofrontal cortex, and dorsolateral frontal cortex were manually drawn. Connectivity to NAc was assessed visually with fractional anisotropy thresholds (20-10). Five densest fiber connections were combined for target selection, aligned to the anterior and posterior commissure, and coordinates and structures were transferred to Gamma Plan for treatment planning. Results: The strongest connections were found between the medial orbitofrontal cortex (mOFC), hypothalamus, ventral tegmental area (VTA), periventricular gray (PVG), and amygdala to the NAc. The mOFC-NAc and the hippocampus-NAc connections are the most and least robust, respectively. Stereotactic coordinates were derived for connectome-based targeting, proposing a 90 Gy dose to the NAc shell, predominantly, and aligning to it the 20 Gy isodose line for neuromodulation. The right and left NAc received > 20 Gy in 75.2% and 55.6% of their volumes, respectively. The optic apparatus received ≤ 5.4 Gy as Dmax.
conclusionRadiosurgery has proved to be a safe modality in the treatment of functional disorders and may offer a new treatment option for refractory addiction. Connectivity-based radiosurgery visualizes most of the NAc connections and may enhance patient-specific targeting.
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