Evidence map›Paper›PMID 41287632›Full record

ReviewPorto biomedical journal

Autoimmune thyroid disease in infertility and assisted reproductive technology: A review.

Maria Inês Pires, Ana Margarida Póvoa, Sandra Silva-Soares

Abstract readReview
In one paragraph

Review in Porto biomedical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Inês PiresFaculty of Medicine, Universidade do Porto, Porto, Portugal.ORCID https://orcid.org/0009-0004-6262-9741
Ana Margarida PóvoaDepartment of Gynecology, Unit of Reproductive Medicine, Centro Hospitalar Universitário São João, Porto, Portugal.ORCID https://orcid.org/0000-0003-0018-9264
Sandra Silva-SoaresDepartment of Gynecology, Unit of Reproductive Medicine, Centro Hospitalar Universitário São João, Porto, Portugal.ORCID https://orcid.org/0000-0002-0552-1417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune thyroid disease (ATD), implicated in infertility and unfavorable outcomes in assisted reproductive technology (ART), is the most prevalent autoimmune disorder among women of reproductive age. This review summarizes the existing evidence on the impact of ATD on infertility and ART outcomes, with a particular focus on screening and therapeutic options. Subclinical hypothyroidism (SCH) frequently coexists with ATD. Thyroid-stimulating hormone (TSH) thresholds for SCH treatment in fertility range from 2.5 to 4.0 mIU/L, causing inconsistencies in clinical management. Although levothyroxine is widely recommended for TSH >4.0 mIU/L, benefits for lower thresholds remain controversial. Immunomodulatory therapies, such as glucocorticoids and intravenous immunoglobulin, have uncertain efficacy in improving ART outcomes. This review highlights the pressing need for standardized diagnostic criteria and therapeutic interventions to optimize fertility outcomes in ATD-positive women, particularly with SCH.

Indexed as

ARTautoimmune thyroid diseaseinfertilitysubclinical hypothyroidismthyroid autoantibodies

Identifiers

PMID41287632
PMCPMC12637338

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.