ArticleInternational journal of women's health2025
Independent Elevation of Leptin and Reduction of Protective Adipokines in Polycystic Ovary Syndrome: A BMI-Matched Case-Control Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Leptin, adiponectin levels and their ratios in women with polyendocrine metabolic ovarian syndrome: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dysregulated inflammatory cytokines and adipokines are implicated in PCOS pathogenesis, but their independent role remains unclear due to the confounding effect of obesity. This study employed a BMI-matched design to specifically investigate adipokine alterations intrinsic to PCOS, independent of body mass. Patients and Methods: This investigation employed a case-control design and included 70 PCOS patients and 82 healthy controls matched for age and BMI. Serum levels of leptin (LEP), interleukin-6 (IL-6), omentin, adiponectin (ADPN), ghrelin, retinol-binding protein 4 (RBP4), and orexin-A (OXA) were measured. Spearman correlation analysis was used to analyze the correlation between PCOS and glucose and lipid metabolism, reproductive hormones and adipokines. Multivariate logistic regression analysis identified independent risk factors for PCOS. Subsequently, the diagnostic capacity of significant variables was appraised using ROC analysis. Results: Compared with healthy controls (n = 82), women with PCOS (n = 70) exhibited significantly higher levels of LEP and IL-6, and significantly lower levels of OXA, omentin, and ADPN/LEP ratio ( Conclusion: This study reveals that patients with PCOS exhibit a specific pattern of adipokine dysregulation, independent of obesity, characterized by elevated LEP coupled with reduced omentin and orexin-A, which may play a pivotal role in disease pathogenesis. These findings highlight the potential clinical value of assessing adipokine profiles and developing targeted interventions, thereby offering novel strategies for the diagnosis and treatment of PCOS.
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