ArticleClinical and experimental reproductive medicine2026
The impact of probiotics on testosterone synthesis in the TM3 cell line.
Article in Clinical and experimental reproductive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the effects of specific probiotic strains on the endocrine activity of Leydig cells, which are essential for testosterone production. We focused on the potential influence of probiotics on testosterone synthesis and mitochondrial functionality within these cells.
methodsThe TM3 Leydig cell line was utilized to assess the effects of three probiotic strains: Lacticaseibacillus rhamnosus, Limosilactobacillus fermentum, and Bifidobacterium longum subsp. longum. The analyses evaluated key aspects of Leydig cell function, including endocrine signaling pathways, cellular proliferation, gene and protein expression related to testosterone biosynthesis, and mitochondrial function.
resultsThe probiotic strains significantly enhanced the expression of key proteins involved in testosterone synthesis and upregulated mitochondrial activity compared to control cells. Notably, these effects were observed across all three probiotic strains, suggesting a positive impact on both testosterone production and mitochondrial function.
conclusionThe findings suggest that probiotic supplementation can modulate testosterone synthesis and improve mitochondrial functionality in Leydig cells. These results underscore the potential of probiotics as modulators of male reproductive health, with possible therapeutic applications in conditions such as male hypogonadism.
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