Evidence map›Paper›PMID 41287530›Full record

ArticleGut microbes2025

Ultra-processed foods sourced 7-ketositosterol aggravates colitis through gut dysbiosis induced-PDLIM3 activation.

Jing Yan, Xiaoqi Pang, Qi Chen, Jingjing Wang, Zimin Wang, Kailin Jiao, Yujie Dai, Ting Xia, Ge Jin, Weilong Zhong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Flavonoids fromFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing YanDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Xiaoqi PangDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Qi ChenDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Jingjing WangDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Zimin WangDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Kailin JiaoDepartment of Nutrition, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Yujie DaiDepartment of Nutrition, the First Affiliated Hospital, Air Force Medical University, Xi'an, China.
Ting XiaState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Ge JinDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Weilong ZhongDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Nan WangDepartment of Nutrition, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Bangmao WangDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Jin ZhengDepartment of Nutrition, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Xin XuDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Hailong CaoDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.ORCID 0000-0002-0147-7826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive ultra-processed foods (UPFs) consumption has been reported to increase the risk of inflammatory bowel disease (IBD). However, the specific mechanisms involved remain unclear. As an important ingredient of UPFs, 7-ketositosterol (KS) is synthesized mainly from high-temperature heated oils. We found that KS intake is higher in IBD patients and is related to disease activity. KS exacerbates colitis in a gut microbiota-dependent manner in mice, altering the gut microbiota composition and increasing the abundance of potential pathogenic bacteria, especially

Indexed as

Adaptor Proteins, Signal TransducingColitisDysbiosisGastrointestinal MicrobiomeLIM Domain ProteinsAnimalsDisease Models, AnimalFemaleFood, ProcessedHumansInflammatory Bowel DiseasesMaleMiceMice, Inbred C57BLNF-kappa BSignal TransductionAdaptor Proteins, Signal TransducingLIM Domain ProteinsNF-kappa B7-ketositosterolcolitisgut microbiotaPDLIM3protein interactionUltra-processed foods

Identifiers

PMID41287530
PMCPMC12931730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.