Evidence map›Paper›PMID 41287496›Full record

ArticleYonsei medical journal2025

Sleep Traits and Risk of Epilepsy: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study.

Yanping Zhu, Gaiying Ma, Minheng Zhang, Hongwei Liu, Xuan Chen, Yu Wang

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Article in Yonsei medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yanping Zhu *Department of Neurology, Taiyuan Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0009-0005-5855-9063
Gaiying Ma *Department of Neurology, Taiyuan Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0009-0004-9178-8354
Minheng ZhangDepartment of Gerontology, The First People's Hospital of Jinzhong, Jinzhong, Shanxi Province, China.ORCID https://orcid.org/0009-0007-3213-6622
Hongwei LiuDepartment of Neurology, Taiyuan Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0000-0003-0979-4364
Xuan ChenDepartment of Neurology, Taiyuan Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0009-0000-2309-0684
Yu WangDepartment of Emergency Internal Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0009-0006-0357-3949

Funding

Basic Research Program of Shanxi Province 20210302124579
6 · The paper itself

Abstract

purposeSleep traits are suggested as risk factors for epilepsy, yet the extent of their shared biological basis and the causal direction between these traits are not well understood. Our goal was to assess the associations and establish causal relationships between sleep traits and epilepsy through Mendelian randomization (MR) analyses. MATERIALS AND

methodsUnivariate and multivariate bidirectional MR analyses were used to assess the causal association between sleep traits and epilepsy. In this study, exposure factors of seven sleep traits and outcome variables related to epilepsy were obtained from the published Genome-Wide Association Study (GWAS). The major analysis utilized for MR was inverse-variance weighted.

resultsUnivariable MR analysis indicated that both insomnia and chronotype were positively associated with the risk of generalized epilepsy (GE) [odds ratio (OR)=3.436, 95% confidence interval (CI): 1.081-10.919,

conclusionOur results suggest a shared genetic foundation between sleep traits and epilepsy, indicating potential causal effect of insomnia on GE risk. Interventions targeting sleep disturbances could serve as therapeutic approaches in epilepsy management.

Indexed as

EpilepsyMendelian Randomization AnalysisSleepGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsSleep Initiation and Maintenance Disordersfocal epilepsygeneralized epilepsyGenome-Wide Association StudyMendelian randomizationSleep traits

Identifiers

PMID41287496
PMCPMC12673657

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