Evidence map›Paper›PMID 41287490›Full record

ArticleOrganic letters2025

Photoinduced Cleavage of Alkenyl Fluorides for Nucleophilic Acyl Substitution via In Situ Generated Acyl Fluorides.

Emma S Gogarnoiu, Melissa S Griffin, Ajay H Bansode, Joshua M Paolillo, Joseph M Bergen, Marvin Parasram

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emma S GogarnoiuDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.ORCID 0000-0002-9317-2770
Melissa S GriffinDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.
Ajay H BansodeDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.
Joshua M PaolilloDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.ORCID 0000-0001-8147-2680
Joseph M BergenDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.
Marvin ParasramDepartment of Chemistry, New York University, 24 Waverly Place, Third Floor, New York, New York 10003, United States.ORCID 0000-0002-6052-0417

Funding

MIRA: C(sp3)-H Heteroatom Incorporation Using Photoexcited NitroarenesR35GM150777 · NIGMS · NEW YORK UNIVERSITY · PI Marvin Parasram · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150777
6 · The paper itself

Abstract

Acyl fluorides are valuable intermediates due to their stability and unique reactivity with amines, enabling selective acyl substitution. We report a mild one-pot method to access amides, esters, and thioesters from alkenyl fluorides. Visible-light photoexcitation of 4-nitrophthalonitrile promotes cleavage of the alkenyl fluoride, forming acyl fluorides in situ for nucleophilic acyl substitution. This protocol offers broad utility as demonstrated in the synthesis of linear peptide fragments.

Identifiers

PMID41287490
PMCPMC12687311

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.