Evidence map›Paper›PMID 41287282›Full record

ArticleOrganic letters2025

Trifluoromethylation of Arenes and Heterocycles via a Bench-Stable Photocaged Trifluoromethylation Reagent.

Gavin J Rustin, Vishal Agarwal, Penelope I Dalton, Zenghui Jiang, Zhao Liu, Isabella G Najor, Bahar Heydari, Beeta Heydari, Nicholas J Kuehl, Vlad Kumirov and 2 more

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gavin J RustinDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Vishal AgarwalDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Penelope I DaltonDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, United States.
Zenghui JiangDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Zhao LiuDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Isabella G NajorDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, United States.
Bahar HeydariDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, United States.
Beeta HeydariDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, United States.
Nicholas J KuehlDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Vlad KumirovDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Michael T TaylorDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-7655-7222
Jeffrey L GustafsonDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0001-7054-7595

Funding

MIRA: Atropisomerism as an inspiration for drug discovery and new chemistryR35GM124637 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Jeffrey Louis Gustafson · 2017 to 2026
$3.8M
New Chemical Tools for Optically Controlled Protein ModificationR35GM143120 · NIGMS · UNIVERSITY OF WYOMING · PI TAYLOR, MICHAEL T · 2021 to 2025
$1.6M
NIGMS NIH HHS R35 GM124637NIGMS NIH HHS R35 GM143120
6 · The paper itself

Abstract

Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid and straightforward trifluoromethylation of diverse aromatics and heterocycles, including complex pharmaceuticals and natural products, with only the substrate, photocage, solvent, and 456 nm light in minutes.

Identifiers

PMID41287282
PMCPMC13081029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.