Evidence map›Paper›PMID 41287126›Full record

ArticlePilot and feasibility studies2025

Evaluating the feasibility and acceptability of study procedures for a full factorial trial of ASCENT: protocol for a randomized pilot.

Karly M Ingram, Rachel Glock, Lane Williamson, AnneMarie Coffey, Reid Anctil, Antonija Augustinovic, DerShung Yang, David Victorson, Alexander M Schoemann, Darla Liles and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Pilot and feasibility studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06420193 (Evaluating the Feasibility and Acceptability of Study Procedures for a Full Factorial Trial of the AYA Survivors Coping and Emotional Needs Toolkit), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06420193 nacompletednot on this map

Evaluating the Feasibility and Acceptability of Study Procedures for a Full Factorial Trial of the AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)

TypeinterventionalSponsorEast Carolina UniversityRan2024 to 2025Enrolled16ConditionsDepression, Cancer, Adolescent, Young AdultArmsAYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karly M IngramDepartment of Psychology, East Carolina University, Greenville, USA. murphykar22@ecu.edu.ORCID http://orcid.org/0000-0001-9174-1338
Rachel GlockDepartment of Psychology, East Carolina University, Greenville, USA.
Lane WilliamsonDepartment of Psychology, East Carolina University, Greenville, USA.
AnneMarie CoffeyDepartment of Psychology, East Carolina University, Greenville, USA.
Reid AnctilDepartment of Psychology, East Carolina University, Greenville, USA.
Antonija AugustinovicDepartment of Psychology, East Carolina University, Greenville, USA.
DerShung YangBrightOutcome Inc., Buffalo Grove, USA.
David VictorsonDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA.
Alexander M SchoemannDepartment of Psychology, East Carolina University, Greenville, USA.
Darla LilesDepartment of Internal Medicine, East Carolina University, Greenville, USA.
John M SalsmanDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, USA.

Funding

iManageAYA: Preparation and Optimization of a mHealth Intervention for Managing Depressive Symptoms in Adolescent and Young adult Cancer SurvivorsR00CA248701 · NCI · EAST CAROLINA UNIVERSITY · PI MURPHY, KARLY MARY · 2023 to 2025
$630k
NCI NIH HHS R00CA248701
6 · The paper itself

Abstract

backgroundAdolescent and young adult cancer survivors (AYACS), aged 15-39, experience higher rates of depressive symptoms (25%-32%) compared to their non-cancer peers or older cancer survivors. While mobile health applications have shown promise in managing physical symptoms, their efficacy in addressing depression in AYACS remains underexplored. This study aims to evaluate the feasibility and acceptability of study procedures for a full factorial trial that will identify the optimal components of a digital tool (ASCENT) designed to promote self-management of depressive symptoms among AYACS.

methodsUsing a full factorial design, we will randomize 16 AYACS who have completed cancer treatment within the past 5 years to 1 of 16 conditions. The primary outcome for this study is the acceptability of study procedures, evaluated via an investigator-developed acceptability survey. Further, semi-structured exit interviews will be conducted to characterize reasons for aspects of the study with sub-optimal acceptability. Quantitative and qualitative data will also be collected on secondary outcomes including the feasibility of study procedures (as measured by recruitment and retention rates), participant use of and engagement with ASCENT, and participant feedback on ASCENT (e.g., usability, acceptability, and satisfaction). DISCUSSION: This pilot trial will assess the acceptability and feasibility of study procedures for a full factorial trial that will optimize a digital tool targeting depressive symptom self-management in AYACS. Findings will inform adjustments to enhance the design and implementation of a fully powered trial.

trial registrationThis trial was prospectively registered in ClinicalTrials.gov (NCT06420193) on May 17, 2024, https://clinicaltrials.gov/study/NCT06420193 . All items from the World Health Organization Trial Registration Data Set are listed in the table below.

Indexed as

Adolescent and young adultCancer survivorshipDepressive symptomsDigital mental healthSelf-managementUser-centered design

Identifiers

PMID41287126
PMCPMC12642116

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.