SynthesisBMC nutrition2025
Dietary intake of total, animal, and plant proteins and risk of chronic kidney disease: systematic review and dose-response meta-analysis of prospective cohort studies.
Synthesis in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Macronutrient mixtures and interactions in health and disease.Nature reviews. Endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveKidney health and dietary protein consumption are incompatible. This study aimed to examine the association between different types of proteins (total, animal, and plant) and chronic kidney disease (CKD).
methodsA comprehensive literature search was conducted in PubMed, Web of Science, and Scopus for articles published up to May 7, 2023. We included prospective cohort studies that reported the association between dietary intake of total, animal, or plant proteins and the risk of CKD, based on predefined eligibility criteria.
resultsTen prospective cohort studies involving 218,741 participants and 10,794 CKD events were included. Meta-analysis indicated that higher intake of animal protein (relative risk [RR] = 0.87, 95% CI: 0.77-0.97; GRADE: high certainty) and plant protein (RR = 0.81, 95% CI: 0.67-0.98; GRADE: moderate certainty) was significantly associated with a reduced risk of CKD. However, no significant association was found between total protein intake and CKD risk (RR = 0.95, 95% CI: 0.75-1.19; GRADE: low certainty). A significant linear dose-response relationship was observed between plant protein intake and lower CKD risk (P < 0.001).
conclusionIn conclusion, while no significant association was observed between total protein intake and CKD risk, both animal and plant protein consumption were associated with a reduced risk. These findings highlight the potential protective role of protein sources in kidney health. Future research should explore the underlying mechanisms of these associations and examine the effects of specific protein sources in diverse populations over longer follow-up periods.
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What OpenQuestion holds
Registered trials
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