ArticleBMC microbiology2025
Epidemiology and genomic characteristics of carbapenem-resistant Klebsiella pneumoniae in intensive care unit from 2021 to 2024.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Epidemiology, Virulence Factors, and Antibacterial Resistance ofMedicina (Kaunas, Lithuania) · 2026Review
- Risk assessment of selected bacterial infections acquired in intensive care units in Poland in the years 2019-2023-analysis with the application of the standardized infection ratio.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeThe primary aim of this research was to elucidate the clinical epidemiology and genetic traits of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and colonization within the intensive care unit (ICU) of a tertiary care teaching hospital in China, spanning the period from 2021 to 2024.
methodsAll CRKP isolates were obtained from patients in the ICU, and relevant clinical data pertaining to these patients were collected. The whole genome sequencing was conducted for all isolates, followed by downstream genomic analyses.
resultsThe study identified 29 non-duplicate CRKP strains, completely isolated from ICU, with sputum as the most common anal swab sample. Patients with factors including a prior ICU stay, use of a central venous catheter and antibiotic treatment were found to be associated with CRKP infection. Our collected CRKP isolates demonstrated multidrug resistance, with additional resistance to cephalosporins. Further virulence assays revealed that these isolates exhibited strong serum survival capabilities despite lacking the mucoid phenotype. Molecular epidemiology indicated that all strains harbored the blaKPC-2 gene and belonged to the KL64-O2v1 serotype. Although all isolates lacked the regulator of mucoid phenotype (rmpA) gene, they carried the colibactin (clb) and yersiniabactin (ybt) genes. These findings suggest a complex interplay between resistance and virulence factors that contribute to the pathogenicity of these CRKP strains.
conclusionThis study provided insights into the molecular epidemiology of CRKP within ICUs from 2021 to 2024, identifying potential factors associated with CRKP infections. Our findings underscore the critical importance of monitoring CRKP and implementing robust antimicrobial stewardship programs to limit the spread of CRKP infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.