ArticleEuropean journal of medical research2025
Efficacy of human-derived fibrin sealant in preventing postoperative adverse events after gastric endoscopic submucosal dissection: a retrospective multicenter study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Fibrin Sealants and Polyglycolic Acid Sheets in Reducing Postoperative Hemorrhage Following Gastric Endoscopic Submucosal Dissection: A Meta-analysis of Randomized and Observational Studies.Journal of gastrointestinal cancer · 2026Pooled it
- Biomaterial-driven remove-remodel-repair (3R) strategy for full-cycle gastric cancer management: bibliometric mapping, preclinical evidence, and a translational roadmap.Nanoscale advances · 2026Review
- A pilot study on the efficacy of cyanoacrylate glue in preventing post-ESD bleeding at the gastric angle.Surgical endoscopy · 2026Article
- Adjunctive fibrin glue for the prevention of bleeding after endoscopic submucosal dissection of gastroesophageal lesions: a systematic review and meta-analysis.Surgical endoscopy · 2026Article
- Comment on "Efficacy of Fibrin Sealants and Polyglycolic Acid Sheets in Reducing Postoperative Hemorrhage Following Gastric Endoscopic Submucosal Dissection: A Meta-analysis of Randomized and Observational Studies".Journal of gastrointestinal cancer · 2026Article
- A pilot study on the application and efficacy of mucosal traction-assisted clip closure in endoscopic full-thickness resection for gastric submucosal tumors.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectivesThe purpose of this study was to evaluate the efficacy of the human-derived fibrin sealant in mitigating adverse events subsequent to endoscopic submucosal dissection (ESD) for the treatment of gastric mucosal lesions.
methodsA retrospective analysis was conducted on data from 661 patients who underwent ESD for gastric mucosal lesions with a resected specimen size ≥ 40 mm. These patients were categorized into the fibrin sealant group and the control group on the basis of postoperative wound management strategies. Comparisons were made between the groups regarding the incidence of adverse events and the postoperative wound healing rate at 1 month. Additionally, factors associated with delayed bleeding following ESD were analyzed.
resultsCompared with the control group, the fibrin sealant group had a significantly lower rate of delayed hemorrhage (1.7% vs. 6.9%; P < 0.001). Subgroup analysis confirmed the consistency of this effect across all the subgroups. Additionally, compared with the control group, the fibrin sealant group had a lower postoperative abdominal pain rate and a lower 24-h postoperative abdominal pain score (P < 0.001). One month after ESD, the fibrin sealant group had a higher wound healing rate (65.4% vs. 51.1%; P = 0.014). Multivariate analysis identified lesions located in the lower one-third of the stomach and specimen size ≥ 60 mm as risk factors for postoperative bleeding.
conclusionThe application of human-derived fibrin sealant to post-ESD wounds effectively decreased the risk of delayed postoperative hemorrhage, mitigated postoperative abdominal pain, and accelerated the healing process of artificial wounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.