ArticleOrphanet journal of rare diseases2025
Dentomaxillofacial abnormalities associated with rare bone disease in two pediatric populations from southern Europe and East Africa.
Article in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Generalized Developmental Enamel Hypoplasia of the Permanent Dentition Associated with Early Childhood Vitamin D Deficiency Rickets: A Case Report.Dentistry journal · 2026Article
- Dentomaxillofacial abnormalities associated with rare bone disease in two pediatric populations from southern Europe and East Africa.Orphanet journal of rare diseases · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well known that certain bone diseases of congenital origin are associated with dentomaxillofacial (DOMF) disorders. The objective of this study was to evaluate and compare the DOMF alterations in pediatric patients with bone diseases in Arusha (Tanzania, East Africa) and Barcelona (Spain, southern Europe). In each area of study, the clinical differences between subgroups of bone diseases in relation to their etiopathogenesis were reported and analysed. MATERIAL &
methodsA cross-sectional study of pediatric patients with bone diseases was carried out at two hospitals, Mount Meru Regional Referral Hospital (MMRRH), Arusha (n = 60) and Hospital Sant Joan de Déu (HSJD), Barcelona (n = 89), from 2019 to 2023. Mean age of the sample was 10.5 years (SD 4.05). In both groups the samples were recruited consecutively and were clinically evaluated for skeletal and DOMF disorders. The different bone pathologies were further divided into two subgroups according to their etiopathogenesis: (i) disorders in cellular metabolism (DCM); (ii) disorders of bone growth/deformity (DGD).
resultsGingival health indexes were significantly better in the HSJD group (p = 0.033). The HSJD group also had better caries indices (DMF-T), though these differences were not significant (p = 0.105). Among dental alterations, dental agenesis was significantly more prevalent in the MMRRH sample (p < 0.001); in this sample, DGD was significantly more frequent than DCM (p = 0.045). Fluorosis was practically non-existent in the HSJD group, but was moderate to severe fluorosis in 26.6% of MMRRH patients and was significantly more prevalent in the MMRRH DCM subgroup (p < 0.001). Malocclusion was more frequent in the MMRRH group (p < 0.001 in the case of Class III inverted overjet and p = 0.008 in the case of crossbite), and in the HSJD group the DCM subgroup presented a more severe overbite and open bite than the DGD subgroup (p = 0.027). Pathological fractures were significantly more frequent in the DGD subgroups in both samples (p < 0.001).
conclusionThere is a clear relationship between dentomaxillofacial abnormalities and rare bone diseases in the two pediatric populations studied. Comparing the two samples, the East African children displayed higher rates of gingivitis, dental fluorosis and malocclusion than their southern European peers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.