Evidence map›Paper›PMID 41286834›Full record

ArticleBMC oral health2025

Serum metabolomics reveals distinctive signature of cancer staging in oral squamous cell carcinoma.

Wen Lu, Linjuan Liu, Jianhong Li, Haoyue Yang, Yongqin Yang, Qingang Hu, Xiaowei Song, Liu Liu, Xihu Yang

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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wen Lu *Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Linjuan Liu *Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Jianhong LiDepartment of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Haoyue YangDepartment of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Yongqin YangDepartment of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Qingang HuDepartment of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, China.
Xiaowei SongDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Liu LiuDepartment of Oral and Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. cycstal2002@126.com.
Xihu YangDepartment of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China. yangxihu1981@126.com.

Funding

Jiangsu Province Graduate Research and Practice Innovation Program KYCX24_4038Key Research and Development Projects of Jiangsu Province BE2022671the National Natural Science Foundation of China 82173380
6 · The paper itself

Abstract

backgroundOral squamous cell carcinoma (OSCC) is the most common form of head and neck cancer. It is of great significance to search for biomarkers associated with OSCC progression through minimally invasive methods.

methodsConductive polymer spray ionization mass spectrometry (CPSI-MS) was used to perform a rapid metabolic analysis of trace volume serum from OSCC and healthy controls. Key metabolites were identified by receiver operating characteristic (ROC) curves and further validated by desorption electrospray ionization mass spectrometry (DESI-MSI) and ultra–high performance liquid chromatography-tandem mass spectrometer (UHPLC-MS/MS).

resultsThe study identified 125 metabolites that significantly differentiated early-stage OSCC from healthy controls. 47 metabolites showed an upward or downward trend in the OSCC staging (I-IV). Through ROC curve analysis and trend assessment of metabolite levels, 10 key metabolites associated with OSCC staging were pinpointed. KEGG pathway enrichment analysis showed that glycerophospholipid metabolism is closely related to OSCC staging. Representative serum metabolites were validated by DESI-MS and UHPLC-MS/MS at tissue level. Kaplan-Meier (KM) survival analysis showed that PC (40:6) was an independent prognostic factor for OSCC.

conclusionWe identified 10 metabolites associated with OSCC staging, and found that glycerophospholipid metabolism may promote the progression of OSCC. Moreover, the key metabolite PC(40:6) is closely related to the prognosis of OSCC.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellMetabolomicsMouth NeoplasmsChromatography, High Pressure LiquidFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryBiomarkers, TumorCancer progressionConductive polymer spray ionization mass spectrometryOral squamous cell carcinomaSerum metabolomics

Identifiers

PMID41286834
PMCPMC12642193

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