SynthesisReproductive biology and endocrinology : RB&E2025
Is sub-endometrial injection a superior method for the administration of intrauterine PRP?: a systematic review and meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endometrial Repair and Regenerative Medicine: From Broad-Spectrum Regeneration to Precision Intervention.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEndometrial platelet-rich plasma (PRP) is proposed to treat thin endometrium and implantation failure. Different techniques are described, and nomenclature is often confusing, with infusion or injection being used interchangeably, not discriminating between methods. Sub-endometrial injection, by hysteroscopic or ultrasound guidance, differs from intracavity infusion, but whether this method is superior has not been subject to review.
methodsA systematic review and meta-analysis was performed to compare sub-endometrial injection against placebo or intra-cavity infusion in a defined assisted reproduction population, with subgroup analysis to assess for any differences between USS-guided or Hysteroscopic Techniques. Primary outcomes were clinical pregnancy (CPR), live birth (LBR), and miscarriage rates (MR).
resultsSignificant increases in CPR (OR = 5.14, p < 0.001) and LBR (OR = 4.60, p < 0.001) were seen in appropriately selected patients with sub-endometrial PRP injection compared to placebo, with a reduction in MR (OR = 0.60, p = 0.036). The benefit of injection compared to infusion appears highest for CPR in those with a resistant thin endometrium (p = 0.03).
conclusionsSub-endometrial administration may improve the efficacy of PRP in selected patients. More work is needed to identify the optimal candidates, and given the additional administration challenges, whether injection should be a first-line intervention, or considered after unsuccessful infusion, remains open to debate, with more studies needed to confirm this.
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