Evidence map›Paper›PMID 41286774›Full record

Observational studyBMC pulmonary medicine2025

Shorten swallowing time and its implication in patients with chronic cough: a prospective observational study.

Li Zhang, Jing Pan, Wenbo Shi, Mengru Zhang, Alimire Aierken, Ran Dong, Qiang Chen, Zhongmin Qiu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Li Zhang *Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, 200072, China.
Jing Pan *Department of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Wenbo Shi *Department of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Mengru ZhangCentre for Clinical Science, Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, UK.
Alimire AierkenDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Ran DongDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Qiang ChenDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Zhongmin QiuDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China. qiuzhongmin@tongji.edu.cn.ORCID http://orcid.org/0000-0002-6612-7413

Funding

Clinical Research Project of Tongji Hospital of Tongji University Nos. ITJ(ZD)2006 and TJ1801the Project of Science and Technology Commission of Shanghai Municipality Nos. 20Y11902500 and 21140903400
6 · The paper itself

Abstract

backgroundPatients with chronic cough (CC) frequently exhibit swallowing dysfunction related to laryngeal hypersensitivity. This study aimed to evaluate the clinical utility of swallowing time (ST) measurement in the etiological assessment and management of CC.

methodsThe ST was measured in 176 patients with CC and 82 healthy controls. Follow-up assessments were conducted among 49 patients with gastroesophageal reflux-associated cough (GERC) and 86 with other causes of CC (non-GERC). Associations between ST and clinical features were analyzed, and the predictive performance of ST for guiding treatment intensification was evaluated in GERC patients and compared with the Hull Airway Reflux Questionnaire (HARQ) and Reflux Symptom Index (RSI).

resultsThe ST was significantly shorter in CC than in healthy controls (1.167 ± 0.446 s vs. 1.798 ± 0.721 s, p < 0.001), and varied significantly among etiological subtypes (p = 0.019). ST was notably reduced in GERC compared to non-GERC patients, showing a specificity of 85.7% but sensitivity of 46.5%. In GERC patients, ST correlated negatively with RSI and HARQ scores, and positively with capsaicin cough threshold (C5). Shorter ST (< 1.015 s) was associated with proximal reflux events and greater need for intensified anti-reflux therapy (χ2 = 17.686, p < 0.001). ST also exhibited superior predictive accuracy over HARQ and RSI scores.

conclusionSwallowing reflex hypersensitivity is prevalent in CC, especially in GERC. ST assessment provides valuable information for etiological differentiation and helps guide optimal treatment intensification in GERC patients.

Indexed as

Chronic CoughCoughDeglutitionDeglutition DisordersGastroesophageal RefluxAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesTime FactorsChronic coughGastroesophageal refluxIrritable larynxSwallowing reflexSwallowing time

Identifiers

PMID41286774
PMCPMC12764120

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.