Evidence map›Paper›PMID 41286749›Full record

ArticleMalaria journal2025

Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages.

Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Aafreen Zehra, Steven Collins Njonte Wouamba, Guy Paulin Kemayou Mouthe, Aubin Youbi Kamche, Darline Dize, Simeon Fogue Kouam, Boniface Pone Kamdem, Jean Claude Tchouankeu and 2 more

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Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mariscal Brice Tchatat TaliAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon. brice.tchatat@facsciences-uy1.cm.
Cedric Derick Jiatsa MbounaAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
Aafreen ZehraTechnology Dissemination & Computational Biology Division, CSIR-Central Institute of Medicinal & Aromatic Plants, P.O.-CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015, Uttar Pradesh, India.
Steven Collins Njonte WouambaDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.
Guy Paulin Kemayou MoutheDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.
Aubin Youbi KamcheAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
Darline DizeAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
Simeon Fogue KouamDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.
Boniface Pone KamdemAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
Jean Claude TchouankeuDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.
Feroz KhanTechnology Dissemination & Computational Biology Division, CSIR-Central Institute of Medicinal & Aromatic Plants, P.O.-CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015, Uttar Pradesh, India.
Fabrice Fekam BoyomAntimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon. boyomf@arhih.cm.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe rising prevalence of artemisinin-resistant malaria parasites in Africa underscores the urgent demand for new and effective therapeutic options. Historically, natural products have demonstrated significant anti-Plasmodium efficacy, indicating their potential as a source for malaria drug discovery. Extracts and fractions from Terminalia ivorensis and Terminalia brownii previously exhibited promising anti-Plasmodium potency; however, a thorough assessment of their pharmacodynamics across all asexual blood stages of Plasmodium falciparum and elucidation of their mode of action remains to be conducted. Products from the active fractions of T. ivorensis (Ti

methodsBoth active fractions (Ti

resultsThe fractionation of Ti

conclusionThis study identifies eschweilenol C as a promising candidate for malaria drug discovery efforts and its significance for further exploration in the context of the emergence of artemisinin-resistant parasites in Africa.

Indexed as

AntimalarialsHemoglobinsPlant ExtractsPlasmodium falciparumTerminaliaHumansTrophozoitesAntimalarialsHemoglobinsPlant ExtractsEschweilenol CMalariaMolecular dockingPharmacodynamicsPharmacokinetics

Identifiers

PMID41286749
PMCPMC12645700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.