ArticleBMC complementary medicine and therapies2025
Anti- inflammatory effects of Andrographis paniculata (Burm.f.) Wall. Ex Nees leaf in LPS-Induced RAW264.7 macrophages.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The inflammatory response is a protective biological response to harmful stimuli involving immune cells and inflammatory mediators. However, chronic inflammation can trigger a variety of inflammatory diseases. In this study, we screened natural products for anti-inflammatory materials. Andrographis paniculata (Burm.f.) Wall. ex Nees (A. paniculata) is used to treat inflammatory diseases in Asia. However, the mechanism of its anti-inflammatory effect is unclear. We analyzed the anti-inflammatory effect of A. paniculata boiling water extract (APW) and A. paniculata 70% EtOH extract (AP70E) and the underlying mechanisms of action. Interestingly, 100 µg/mL AP70E suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nitric oxide (NO) production to a significantly greater degree than APW. In addition, 100 µg/mL AP70E significantly inhibited the LPS-induced production of the pro-inflammatory cytokines interleukin (IL)-1β and IL-6 and suppressed the mitogen-activated protein kinase (MAPK) and Janus kinase (JAK)/signaling transducer and activator of transcription (STAT) signaling axes. Moreover, it significantly reduced the activity of the JAK/STAT axis independently of its reduction of pro-inflammatory cytokine production. In conclusion, AP70E has potential as an anti-inflammatory agent.
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