Observational studyBMC cancer2025
Association between body-mass index change and lung cancer risk in Korea: nested case-control study.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated an association between body mass index (BMI) and lung cancer risk, while additional research has found that BMI change affects lung disease. This study aims to investigate the association between BMI changes with lung cancer risk in Korea.
methodsWe identified 18,941 patients diagnosed with lung cancer for the first time between 2018 and 2022 using the Korean National Health Insurance claims database. A nested case-control design was applied with 1:5 age, sex and year matching, resulting in 94,705 controls. BMI change variables included the magnitude of change in BMI, rates, and groups of rates. Odds ratios for cancer risk were estimated using conditional logistic regression, adjusted for covariates. Subgroup analyses were conducted based on obesity classification and smoking status.
resultsOf 113,646 individuals (87,912 [77.4%] male), underweight individuals had a higher risk (OR, 1.22; 95% CI, 1.10–1.34) compared to normal-weight individuals, whereas overweight (OR, 0.91; 95% CI, 0.88–0.95) and obese (OR, 0.83; 95% CI, 0.80–0.86) individuals showed reduced risk. A decrease in BMI was associated with increased lung cancer risk (OR, 0.97; 95% CI, 0.96–0.98), particularly among normal-weight (OR, 0.96, 95% CI: 0.94–0.99) and obese (OR, 0.96, 95% CI, 0.94–0.99) individuals.
conclusionsThe impact of BMI decrease on lung cancer risk was most pronounced among current smokers, followed by ex-smokers and non-smokers. The association between BMI change and lung cancer risk was confirmed. As a predictive factor, BMI change could be assessed during health examinations as an indicator for cancer screening.
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