ArticleBMC nephrology2025
Associations between estimated glucose disposal rate and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors of hyperuricemia and gout in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China.Frontiers in nutrition · 2026Article
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6 authors.
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Abstract
backgroundThe estimated glucose disposal rate (eGDR) is a novel surrogate for insulin resistance (IR). While it has shown potential in cardiovascular and metabolic outcomes, its relationship with hyperuricemia remains unclear. Therefore, this study aims to explore the association between eGDR and hyperuricemia in patients with type 2 diabetes mellitus (T2DM).
methodsA total of 1,238 patients with T2DM were included in this cross-sectional study. eGDR was calculated using waist circumference, hypertension diagnosis, and HbA1c values measured at baseline. Logistic regression models were used to evaluate the association between eGDR and hyperuricemia. Stratified and interaction analyses were performed to confirm the reliability of the results.
resultsThe prevalence of hyperuricemia was 29.7% in our study. After adjusting for potential confounders, each standard deviation (SD) increase in eGDR was associated with 17% lower odds of hyperuricemia (OR = 0.83, 95% CI: 0.72-0.95, P < 0.001). This significant negative association between eGDR and hyperuricemia remained consistent when eGDR was analyzed in tertiles. Subgroup analyses showed that lower eGDR levels were associated with higher odds of hyperuricemia across all subgroups, with no significant interaction effects.
conclusionseGDR was inversely associated with hyperuricemia in Chinese patients with type 2 diabetes mellitus.
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