ArticleBMC infectious diseases2025
Capillary leak syndrome in sepsis: the role of intrinsic coagulation pathway activation.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Biomimetic Targeted Drug Delivery for Liver Failure in Abdominal Sepsis: Focus on Autologous Erythrocyte Ghosts.International journal of molecular sciences · 2026Review
- Article
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10 authors.
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Abstract
backgroundThe coagulation system is closely linked to the inflammatory response and kinin system activation in sepsis, but its contribution to sepsis-associated capillary leak syndrome (SACLS) remains elusive. This study explored the underlying role of the coagulation system in SACLS.
methodsPatients with sepsis were recruited to evaluate the early predictive potential of coagulation function-related indicators for capillary leakage. Patients with hemorrhagic fever with renal syndrome (HFRS) and scrub typhus, conditions featuring SACLS as a typical manifestation, were selected to validate the predictive value of coagulation-related indicators in SACLS. The levels of coagulation factors in patients with sepsis were analyzed to elucidate the altered mechanisms in the coagulation system. Additionally, rat SACLS models were established via an intravenous injection of lipopolysaccharide to corroborate the changes and potential effects of the coagulation system during SACLS.
resultsProthrombin time (PT) and activated partial thromboplastin time (APTT) exhibited predictive potential for diagnosing capillary leak syndrome in patients with sepsis. APTT displayed higher sensitivity than PT in detecting SACLS at an early stage. Compared with the findings in patients with sepsis and normal APTT, the activities of coagulation factor Ⅺ (FXI) and FXII in plasma and levels of complement 3 and 4 in serum were significantly decreased in patients with APTT prolongation (all P < 0.05) and negatively correlated with APTT prolongation (all P < 0.05). FXI and FXII activities were decreased in the plasma of SACLS model rats (P < 0.001). Conversely, FXII and complement levels were elevated in the lungs (both P < 0.05), accompanied by elevated bradykinin levels (P < 0.001).
conclusionsAPTT is a sensitive indicator for predicting SACLS. APTT prolongation in plasma might be attributable to the enrichment of FXII in the microcirculation. The microcirculatory enrichment of FXII might activate the kinin and complement systems, contributing to the process of capillary leakage.
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