ArticleBMC microbiology2025
Global transcriptional regulation by the CodY gene: identification of critical compounds that enhance oxidative stress resistance in Lactobacillus delbrueckii subsp. Bulgaricus.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCodY (Control of dppY) is a global transcriptional regulator of Streptococcus thermophilus (ST). In this study, we utilized a S. thermophilus codY gene deletion mutant strain to explore metabolites that may affect the oxidative-stress resistance of Lactobacillus delbrueckii subsp. bulgaricus. The context of this research is to understand the role of CodY in the interaction between S. thermophilus and L. delbrueckii, particularly focusing on the impact of CodY on the oxidative-stress resistance of L. delbrueckii.
resultsFirstly, the ST-1ΔcodY mutant strain was constructed by the knockout technique. We found that codY gene deletion significantly reduced the growth rate and resistance to oxidative stress of L. delbrueckii in co-culture, with a decrease in viable bacterial count to 5.26 ± 0.04 log(cfu/mL), and a decrease in survival by 15% and 25% under 5 mM and 10 mM H
conclusionsThe study results are important for understanding the synergistic effect of the two bacteria during fermentation and their response to environmental stresses. The findings provide insights into the role of CodY in modulating the oxidative-stress resistance of L. delbrueckii and highlight the potential of identified metabolites to enhance the performance of this bacterium under stress conditions. This could have implications for the development of strategies to improve the robustness of industrial fermentation processes involving these bacteria.
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