Evidence map›Paper›PMID 41286578›Full record

ArticlePharmacology research & perspectives2025

Impact of Dihydrocapsaicin on the Metabolism of Efavirenz In Vitro and In Vivo.

Bo Wang, Xu Ma, Xinggao Wang, Yuxuan Chen, Quan Zhou, Abdullah Al Mamun, Guozhen Wang, Shuanghu Wang, Xiaoxin Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo WangDepartment of Orthopaedics, The Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Xu MaDepartment of Pediatric Orthopaedics, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
Xinggao WangDepartment of Orthopaedics, The Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Yuxuan ChenDepartment of Orthopaedics, The Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Quan ZhouKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Abdullah Al MamunKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.ORCID 0000-0001-9936-3925
Guozhen WangDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Shuanghu WangKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.ORCID 0000-0002-0057-267X
Xiaoxin MaDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Funding

City Level Key Research and Development Project of Lishui 2023zdyf15Medical and Health Research Project of Zhejiang Province 2022RC303Medical and Health Research Project of Zhejiang Province 2024KY580WBE Liver Fibrosis Foundation CFHPC20171007Youth Fund of National Natural Science Foundation of China 81800544
6 · The paper itself

Abstract

Efavirenz (EFV) is the first-line treatment for acquired immunodeficiency syndrome. However, capsaicin may affect its properties, although the underlying mechanisms remain unknown. This study aimed to investigate the effects of dihydrocapsaicin (DHC) on the pharmacokinetics of EFV both in vivo and in vitro. Twelve Sprague-Dawley rats were divided into two groups including experimental and control. The experimental group was pretreated with DHC (10 mg/kg/day) for two weeks with 5% sodium carboxymethyl cellulose prior to receiving EFV. After a single-dose oral administration of 56 mg/kg EFV, blood samples (50 μL) were collected from the caudal vein and analyzed. The effects of DHC on EFV in vitro were further studied in rat liver microsomes (RLMs). The area under the plasma concentration-time curve for EFV increased from 8821.45 ± 2877.31 to 22347.15 ± 7579.96 μg/mL/h (p < 0.05); the maximum plasma time increased from 2.50 ± 0.84 to 3.50 ± 0.55 h (p < 0.05) and elimination half-life increased from 3.13 ± 0.87 to 3.51 ± 0.79 h (p < 0.05). In contrast, the plasma clearance rate decreased from 6.71 ± 2.48 to 2.65 ± 0.98 L/h/kg (p < 0.05) in the experimental group compared to that in the control group. Additionally, the results showed that DHC significantly inhibited the metabolism of EFV in RLMs. Drug-drug interactions were observed between DHC and EFV, altering the pharmacokinetics of EFV both in vivo and in vitro. The dosage of capsaicin should be monitored and adjusted in patients receiving EFV maintenance therapy.

Indexed as

Anti-HIV AgentsBenzoxazinesCapsaicinReverse Transcriptase InhibitorsAdministration, OralAlkynesAnimalsArea Under CurveCyclopropanesDrug InteractionsMaleMicrosomes, LiverRatsRats, Sprague-DawleyAlkynesAnti-HIV AgentsBenzoxazinesCapsaicinCyclopropanesdihydrocapsaicinefavirenzReverse Transcriptase Inhibitorsacquired immunodeficiency syndromeCYP450dihydrocapsaicindrug–drug interactionpharmacokinetics

Identifiers

PMID41286578
PMCPMC12643817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.