Evidence map›Paper›PMID 41286549›Full record

ArticlePhotochemistry and photobiology

Transcriptional benchmark dose modeling of ultraviolet radiation-induced genomic activation in mouse skin.

Sami S Qutob, Samantha P M Roesch, Sandy Smiley, Pascale V Bellier, Andrew Williams, Kate B Cook, Matthew J Meier, Andrea Rowan-Carroll, Carole L Yauk, James P McNamee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sami S QutobConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Samantha P M RoeschConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Sandy SmileyConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Pascale V BellierConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Andrew WilliamsEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Kate B CookEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Matthew J MeierEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Andrea Rowan-CarrollEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Carole L YaukDepartment of Biology, University of Ottawa, Ottawa, Ontario, Canada.
James P McNameeConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Vinita ChauhanConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vivo transcriptional response of mouse skin to ultraviolet radiation (UV-R) exposure reveals key genomic alterations associated with UV-R-induced damage but it does not provide precise dose thresholds for these effects. These initial findings provided the impetus to advance dose-response characterization by integrating benchmark dose (BMD) modeling with transcriptomic data, aiming to identify biologically relevant points of departure for gene and pathway activation. To accomplish this, mice were exposed to five erythemally weighted UV-R doses (0-40 mJ/cm

Indexed as

SkinTranscription, GeneticUltraviolet RaysAnimalsDNA DamageDose-Response Relationship, RadiationFemaleMiceOxidative StressTranscriptomeDNA damagedose‐dependent changesin vivolowest consistent response dosesoxidative stressskin cancertanningtranscriptional changestranscriptomic point of departure determinationultraviolet radiation

Identifiers

PMID41286549
PMCPMC13575721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.