ArticleNeurocritical care2026
Dynamic of Cerebrospinal Fluid and Acute-Phase Proteins After Subarachnoid Hemorrhage: The Lumbar Compartment as Blind Spot?
Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rupture of an intracranial aneurysm, resulting in aneurysmal subarachnoid hemorrhage (aSAH), constitutes a devastating neurological event marked by an abrupt clinical onset and high morbidity and mortality rates. Controlled lumbar drainage following aSAH has been associated with improved neurological outcomes; however, the underlying mechanisms remain poorly understood. This study aims to characterize the lumbar and cranial cerebrospinal fluid (CSF) compartments and contrast these with serum laboratory test findings, providing a foundational framework for future investigations into the mechanisms by which lumbar drainage facilitates neurological recovery.
methodsWe retrospectively included patients with aSAH for whom CSF specimens were available. Baseline demographic data, serum laboratory test results, and CSF findings were collected following the hemorrhagic event. A CSF infection was defined as a positive microbiological culture result.
resultsWe included 454 patients, with a total of 7,176 serum samples and 1,911 CSF samples. All patients showed an initial increase in acute-phase protein levels, with a decline afterward, and these dynamics revealed a significant effect of lumbar drainage. Lower C-reactive protein (CRP) levels were observed when using a lumbar drain (p < 0.001). Furthermore, CRP levels peaked earlier and consecutively declined earlier with the use of lumbar drains (p < 0.001). Similarly, leukocyte levels were higher in patients without lumbar drainage (p = 0.002). The majority of blood cells were detected in the lumbar CSF compartment. Notably, the differences between the lumbar and ventricular CSF compartments persisted for up to five days post hemorrhage.
conclusionsVentricular and lumbar CSF compartments exhibit significant differences within the first days following aSAH. These findings suggest that blood cell accumulation in the lumbar compartment may contribute to post-aSAH inflammatory processes. Accordingly, the source of CSF samples should be carefully considered to ensure accurate interpretation and to guide therapeutic decision-making in the management of aSAH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.