ArticleCommunications biology2025
Distinct responses to non-autonomous UPR
Abstract read
In one paragraph
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity.Genes & development · 2026Article
- Heat stress reveals bidirectional cross talk between the heat shock response and UPRER in C. elegans.G3 (Bethesda, Md.) · 2026Article
- Exploring non-autonomous protein homeostasis driven by glutamatergic neurons.microPublication biology · 2026Article
Corrections and comments
- Update of
Authors and funding
20 authors.
Aeowynn J Coakley *Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9753-2198
Adam J Hruby *Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Jing WangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Andrew BongLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Tripti NairLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5380-4622
Carmen M RamosLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8508-3308
Athena AlcalaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Daniel HicksLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0003-0314-8481
Maxim AverbukhLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Naibedya DuttaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Darius MoaddeliLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Camilla PearsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Cynthia J SiebrandLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5422-1835
Mattias de Los Rios RogersDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3879-4526
Arushi SahayDepartment of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8284-8034
Sean P CurranLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7791-6453
Peter J MullenDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7401-4777
Gilberto GarciaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. ggarcia1@usc.edu.ORCID http://orcid.org/0000-0001-9959-650X
Ryo Higuchi-SanabriaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. ryo.sanabria@usc.edu.ORCID http://orcid.org/0000-0001-8936-5812
Funding
Wormbase SupplementP41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 2000 to 2012
$32.0MWormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5MWormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MUSC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3MAge-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasisR01AG058610 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CURRAN, SEAN P · 2019 to 2023
$2.1MWhen actin’s not actin like actin: Nuclear actin impacts transcription and agingR01AG079806 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Ryo Higuchi-Sanabria · 2024 to 2026
$1.9MMore than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747kCell autonomous and cell non-autonomous roles for mitochondrial proline catabolism in health and longevityF31AG090069 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RAMOS, MARIA CARMEN · 2024 to 2024
$42kNHGRI NIH HHS P41 HG002223NHGRI NIH HHS U24 HG002223NHGRI NIH HHS U41 HG002223NIA NIH HHS F31 AG090069NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG058610NIA NIH HHS R01 AG079806NIA NIH HHS T32 AG052374NIH HHS P40 OD010440Simons Foundation SF811217U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) F31AG090069U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R00AG065200U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) T32AG052374
Abstract
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsGlutamic AcidNeuronsUnfolded Protein ResponseAnimalsEndoplasmic Reticulum StressSignal TransductionCaenorhabditis elegans ProteinsGlutamic Acid
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.