ArticleAnalytical and bioanalytical chemistry2026
Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Migration and Safety Assessment of 20 Antioxidants in 39 Disposable Biodegradable Tableware Products.Foods (Basel, Switzerland) · 2026Article
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9 authors.
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Abstract
2,4-Di-tert-butylphenol (DTBP) is a degradation product of the antioxidant plastic additive tris(2,4-di-tert-butylphenyl)phosphite and was shown to migrate from different plastics. Additionally, several natural sources for DTBP are known, together leading to exposure of the general population. Human biomonitoring (HBM) can be applied to determine the prevalence and also the magnitude of internal DTBP exposure. To this effect, we have developed a column-switching UHPLC-MS/MS method permitting the quantification of DTBP and a postulated metabolite, 2-tert-butyl-4-(2-hydroxy-1,1-dimethylethyl)phenol (DTBP-4-OH), in urine, after enzymatic cleavage of glucuronides. Since DTBP-4-OH was not available commercially, we synthesised it as a reference material, along with a deuterated analogue to be used as an internal standard for the analytical method. The method was validated, inter alia with regard to its precision, accuracy, robustness, and limit of quantification (LOQ). For both biomarkers, an LOQ of 1 µg l
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