Evidence map›Paper›PMID 41286405›Full record

ArticleNPJ precision oncology2025

Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association.

Avishai Wizel, Matthew D A Spence, Michael Mints, William Britton, Ogoegbunam Okolo, Victoria Yu, Isabel Cioffi, Salvatore Caruana, Scott H Troob, William C Faquin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Avishai Wizel *The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Matthew D A Spence *Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Michael MintsDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
William BrittonColumbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Ogoegbunam OkoloColumbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Victoria YuDepartment of Otolaryngology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Isabel CioffiHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Salvatore CaruanaDepartment of Otolaryngology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Scott H TroobDepartment of Otolaryngology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
William C FaquinDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Derrick T LinDepartment of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
Itay TiroshDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Sidharth V PuramDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA.
Anuraag S ParikhDepartment of Otolaryngology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA. asp2145@cumc.columbia.edu.
Yotam DrierThe Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. yotam.drier@mail.huji.ac.il.

Funding

3D Culture Models of Partial-EMT and Its Regulation in Oral Cavity Squamous Cell CarcinomaK08DE033093 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARIKH, ANURAAG SUHRID · 2023 to 2025
$827k
H2020 European Research Council 949029NCI NIH HHS 1K08CA237732NIDCR NIH HHS 1K08DE033093NIDCR NIH HHS K08 DE033093
6 · The paper itself

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a rare tumor that morphologically resembles high-grade adenoid cystic carcinoma (ACC) but exhibits indolent clinical behavior. Both demonstrate MYB proto-oncogene upregulation, though HMSC lacks the MYB translocation characteristic of ACC. We performed single-cell RNA sequencing on an HMSC tumor and compared expression patterns with published ACC and oropharyngeal squamous cell carcinoma (OPSCC) datasets. Malignant HMSC cells clustered separately from ACC and lacked bicellular luminal and myoepithelial differentiation. A greater proportion of HMSC cells expressing HPV-related genes (HPVon) expressed MYB (83% vs. 62%, p = 0.022) and MYB targets (p = 6.4 × 10

Identifiers

PMID41286405
PMCPMC12644561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.