Evidence map›Paper›PMID 41286391›Full record

ArticleOncology and therapy2026

Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults.

Savio George Barreto, Irit Ben-Aharon, Cathy Eng, Shailesh V Shrikhande, Bhawna Sirohi, Kjetil Søreide, Stephen J Pandol

Abstract readEditorial
In one paragraph

Article in Oncology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Savio George BarretoDepartment of Surgery, Flinders Medical Centre, Bedford Park, Adelaide, SA, 5042, Australia. georgebarreto@yahoo.com.ORCID http://orcid.org/0000-0002-4999-5657
Irit Ben-AharonDivision of Oncology, Rambam Health Care Center, Haifa, Israel.
Cathy EngVanderbilt Ingram Cancer Center, Nashville, TN, USA.
Shailesh V ShrikhandeGI and HPB Services, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
Bhawna SirohiDepartment of Medical Oncology, Vedanta Medical Research Foundation-Balco Medical Centre, Raipur, Chhattisgarh, India.
Kjetil SøreideDepartment of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.
Stephen J PandolDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GUKOVSKAYA, ANNA S. · 2014 to 2018
$8.1M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
Targeting protein kinase D in alcoholic pancreatitisR01AA024464 · NIAAA · CEDARS-SINAI MEDICAL CENTER · PI PANDOL, STEPHEN J., YUAN, JINGZHEN · 2016 to 2020
$2.0M
Flinders Foundation 49358025National Health and Medical Research Council 2021009National Institute of Health (US) P50 AA0119991NIAAA NIH HHS R01 AA024464NIDDK NIH HHS P01 DK098108NIDDK NIH HHS U01 DK108314PanKind, The Australian Pancreatic Cancer Foundation 21.R7.INV.CB.UOSA.6.2U.S. Department of Defense W81XWH1910888
6 · The paper itself

Abstract

With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.

Indexed as

OutcomesResearchYoung-onset

Identifiers

PMID41286391
PMCPMC12992724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.