ArticleCommunications biology2025
Molecular mechanisms limiting the AAV gene therapy treatment window in mouse models of blue cone monochromacy.
Brooke A Brothers, Emily R Sechrest, Li Ma, Madyson E Ashcraft, Tongju Guan, Robert J Barbera, Lee M Shaw, Becky Chen, Wolfgang Baehr, Gangqing Hu and 2 more
Abstract read
In one paragraphArticle in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Emily R Sechrest *Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Li Ma *Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.
Madyson E Ashcraft *Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Tongju GuanDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Robert J BarberaDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Lee M ShawDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Becky ChenDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, USA.
Wolfgang BaehrDepartment of Ophthalmology, John A. Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Funding
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0MWV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1MWVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4MVS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Shian Liu · 2022 to 2026
$13.9MRETINAL PHOTORECEPTOR CYCLIC GMP PHOSPHODIESTERASER01EY008123 · NEI · UNIVERSITY OF UTAH · PI BAEHR, WOLFGANG · 1990 to 2019
$7.8MPhotoreceptor neuron specific alternative splicing of messenger RNAR01EY025536 · NEI · WEST VIRGINIA UNIVERSITY · PI RAMAMURTHY, VISVANATHAN, STOILOV, PETER · 2016 to 2023
$3.3MDisease mechanisms of cone opsin mutants and treatment strategiesR01EY030056 · NEI · WEST VIRGINIA UNIVERSITY · PI DENG, WEN-TAO · 2019 to 2023
$1.9MRecombinase-free conditional knock-in through alternative splicingR21EY036144 · NEI · WEST VIRGINIA UNIVERSITY · PI STOILOV, PETER · 2024 to 2025
$418kFoundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) EY014800-039003NEI NIH HHS R01 EY008123NEI NIH HHS R01 EY025536NEI NIH HHS R01 EY030056NEI NIH HHS R21 EY036144NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P20 GM144230NIGMS NIH HHS U54 GM104942
6 · The paper itselfAbstract
Blue cone monochromacy (BCM) is a severe X-linked blinding disorder caused by mutations in the OPN1LW/OPN1MW locus, resulting in impaired cone function and structural degeneration. We conduct a comparative analysis of AAV gene therapy in Opn1mw
Indexed as
Color Vision DefectsDependovirusGenetic TherapyRetinal Cone Photoreceptor CellsAnimalsDisease Models, AnimalGenetic VectorsMiceMice, Inbred C57BLMice, KnockoutRod OpsinsRod Opsins
Identifiers
PMID41286353
PMCPMC12644701
What OpenQuestion holds
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LicenceCC BY-NC-ND
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