Evidence map›Paper›PMID 41286257›Full record

ArticleScientific reports2025

Long COVID: lung pathophysiology and its relationship with cognitive dysfunction.

Keegan R Staab, Marrissa J McIntosh, Abhilash S Kizhakke Puliyakote, Andrew D Hahn, Natally AlArab, Jonathan L Percy, Tara Lanning, Johanna Theeler, Carinda Linkenmeyer, Conner J Wharff and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Psychometric evaluation of PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Keegan R StaabRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, US.
Marrissa J McIntoshDepartment of Radiology, University of Iowa, Iowa City, IA, US.
Abhilash S Kizhakke PuliyakoteDepartment of Radiology, University of Iowa, Iowa City, IA, US.
Andrew D HahnDepartment of Radiology, University of Iowa, Iowa City, IA, US.
Natally AlArabDepartment of Radiology, University of Iowa, Iowa City, IA, US.
Jonathan L PercyDepartment of Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.
Tara LanningDepartment of Psychiatry, University of Iowa, Iowa City, IA, US.
Johanna TheelerDepartment of Psychiatry, University of Iowa, Iowa City, IA, US.
Carinda LinkenmeyerDepartment of Psychiatry, University of Iowa, Iowa City, IA, US.
Conner J WharffDepartment of Radiology, University of Iowa, Iowa City, IA, US.
Eric BrueningInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA, US.
Jessica C SierenRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, US.
Eric A HoffmanRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, US.
Alejandro P ComellasDepartment of Internal Medicine, University of Iowa, Iowa City, IA, US.
Karin F HothDepartment of Psychiatry, University of Iowa, Iowa City, IA, US.
Sean B FainRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, US. sean-fain@uiowa.edu.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Dynamic Imaging of Lung Ventilation and Perfusion Using CT and MRIR01HL169765 · NHLBI · UNIVERSITY OF IOWA · PI Sean Bedilion Fain · 2023 to 2026
$2.9M
Hyperpolarized Xe-129 MRI for Functional Lung PhenotypingS10OD026960 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2019 to 2019
$600k
American Lung Association COVID-19 and Emerging Respiratory Viruses Research AwardNCATS NIH HHS UM1 TR004403NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL169765NIEHS NIH HHS P30 ES005605NIH HHS NIH NCATS S10OD026960, NIH CTSA program grant UM1TR004403, NIH NHLBI R01HL169765, NIH NHLBI R01HL126771NIH HHS S10 OD026960
6 · The paper itself

Abstract

Post-acute sequelae of COVID-19 (Long COVID) includes physical and cognitive symptoms that can last long after acute infection. Links between lung pathophysiology and cognitive dysfunction in Long COVID remain largely unexplored. Long COVID participants were recruited from a post-COVID-19 clinic. Participants completed Patient-Reported Outcomes Measurement Information System (PROMIS) symptom questionnaires for Sleep Disturbance, Anxiety, Depression, and Cognitive Function, the National Institute of Health Toolbox Cognition Battery (NIHTB-CB), pulmonary function tests (spirometry, diffusion capacity of the lung), structural and functional brain magnetic resonance imaging (MRI), and

Indexed as

Cognitive DysfunctionCOVID-19LungAdultAgedAnxietyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPost-Acute COVID-19 SyndromeRespiratory Function TestsSARS-CoV-2Sleep Wake Disorders

Identifiers

PMID41286257
PMCPMC12663264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.